Am J Gastroenterol 1999 Aug;94(8):2296-7
High alpha-fetoprotein level in HCV-related nodular liver cell dysplasia
Ng FH, Chow KC, Cheng CS,
Kng C, Ng WF, Wong BC
Department of Medicine, Ruttonjee Hospital, Wan Chai, Hong Kong, China.
The diagnosis of hepatocellular carcinoma is generally made in patients with a mass lesion in the cirrhotic liver if the alpha-fetoprotein level is >1,000 ng/L. Other causes of elevation of alpha-fetoprotein to this extreme degree include nonseminomatous germ cell tumor and hepatic metastasis. However, it is extremely rare for benign hepatic lesions to cause alpha-fetoprotein of > 1,000 ng/ml. We report a Chinese patient with spontaneous normalization of alpha-fetoprotein with an initial value > 10,000 ng/ml due to nodular dysplasia complicating hepatitis C-related liver cirrhosis. The alpha-fetoprotein was secreted from the dysplastic liver cells.
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